Sustained-release Capsules

Hubei Kornnac Pharmaceutical Co., Ltd. is one of the most reliable manufacturers and suppliers of sustained-release capsules in China, also supports customized service and OEM service. Welcome to buy bulk high quality sustained-release capsules at competitive price from our factory. Contact us for samples.

‌Sustained-release capsules‌ are a dosage form designed to gradually release medication in the body using specialized formulation technology, extending therapeutic duration and reducing dosing frequency. Their controlled release mechanism maintains stable blood drug concentration to optimize therapeutic effectiveness. For example, ibuprofen sustained-release capsules continuously release the drug over time, providing prolonged pain relief and fever reduction.

By utilizing special coating technology of drug particles or micropellets in capsules, or using excipients with sustained-release properties, the drug can be slowly released through mechanisms such as diffusion and dissolution.

▶Equipped with PTS Production Lines：Featuring an intelligent sol-gel system, automatic viscosity adjustment equipment, Automatic Guided Vehicle (AGV) system, and vacuum pipeline capsule transmission. These fully-automated operations ensure high production efficiency, process traceability, and superior product quality through core technological support.

 

▶Through fully automated control operations, strict indoor cleaning procedure and quality monitoring, and constant temperature and humidity process conditions, ethylene oxide-free sterilization is achieved;

 

▶Achieved through fully automated operations, strict indoor cleaning protocols, rigorous quality monitoring, and controlled temperature and humidity conditions. This ensures product safety without the use of ethylene oxide sterilization.

 

▶The size of new capsule mold matches with existing mainstream filling machine. Professional technical service team for the service from pre-sale to after-sales to help to improve capsule filling rate;

 

▶Gain CNAS Certification for Laboratory.

• KornnacCaps is in accordance with GMP standards, uses high-quality and high-tech automatic capsule manufacturing machinery, adheres to the production philosophy of Excellence, Perfect Quality, and follows multi-channel strict quality management to ensure the perfect quality of Kornnac capsules.

 

• Strict production management is enforced through the implementation of 6S on-site management standards, effectively preventing issues such as batch mixing and cross-contamination, and ensuring comprehensive protection throughout the production process.

Control

Following cGMP Standards for Production and Quality Management
KornnacCaps adheres strictly to current Good Manufacturing Practices (cGMP) in organizing production and quality control. A comprehensive quality assurance system has been established, and our laboratory is in the process of obtaining CNAS certification to further validate our scientific rigor and testing capabilities.

Quality Objectives

Achieve a 100% pass rate in product market sampling

Maintain zero significant quality and safety incidents

Continuously lead the industry in product and service standards

Our product complies with the standards of the Chinese Pharmacopoeia and has passed international certifications such as HALAL,Kosher,FDA,ISO9001 and ISO22000.

1.Fast lead time with guaranteed supply for all orders

2.12-hour rapid response to quality issues, with joint support from sales, technical, and after-sales teams technical and after-sales departments will make a joint response;

3.Free training on filling machine operation, maintenance, and capsule inspection

4.Provide filling machine installation, debugging, repair and maintenance services free of charge, and assist customers in ordering filling machine spare parts;

5.Free samples available for testing and approval

6.Comprehensive after-sales technical support;

7.Customized capsules according to the characteristics of customer powder

• PE bag+Aluminum foil bag+Six surface foam board+5 ply corrugated Carton;

 

• Carton size 60x73x40cm,volume 0.18 cubic meters, gross weight is about 15kgs per box;

 

• 20' Refrigerator Container : 140 cartons empty capsules;

 

• 40' Refrigerator Container: 345 cartons empty capsules;

 

• After the product inspection, we will promptly arrange special vehicles, refrigerated vehicles, air consignments, express and other services according to customer needs to effectively meet the supply needs of different customers.

 

Available for customization according to the customer's requirements.

Comparison of Advantages between Sustained-Release Capsules and Ordinary Empty Capsules

1. Drug Release Mechanism
Sustained-release empty capsules: Through special designs such as dissolution type, diffusion type, osmotic pump type, or ion exchange type, the release rate of the drug in the body is controlled, allowing the drug to be released at a relatively constant rate, thereby prolonging the duration of drug action.
Ordinary Empty capsules: The drug usually releases rapidly after entering the body, reaching a peak blood drug concentration in a short period of time, and then gradually decreases, which may lead to a short duration of drug action and large fluctuations in blood drug concentration.

2. Blood Drug Concentration Stability
Sustained-release empty capsules: Due to the slow release of the drug, the blood drug concentration remains relatively stable, avoiding the "peak-valley" phenomenon caused by rapid release in ordinary capsules. This stability can reduce drug side effects and improve treatment efficacy.
Ordinary empty capsules: The blood drug concentration fluctuates greatly, which may lead to side effects at high concentrations and insufficient efficacy at low concentrations.

3. Convenience of Taking
Sustained-release empty capsules: Generally, they only need to be taken 1-2 times a day, reducing the frequency of taking medication and improving patients' medication compliance.
Ordinary empty capsules: They usually need to be taken multiple times a day, increasing the possibility of forgetting to take medication and reducing medication compliance.

4. Gastrointestinal Stimulation
Sustained-release capsules: By slowly releasing the drug, the stimulation of the gastrointestinal tract is reduced, making them suitable for patients who need long-term medication.
Ordinary empty capsules: The rapid release of the drug may cause significant stimulation to the gastrointestinal tract, especially for some strong drugs.

5. Drug Stability
Sustained-release capsules: The capsule shell protects the drug from external environments (such as humidity and oxygen), and through special processes, improves the stability of the drug in the body.
Ordinary empty capsules: The drug protection performance is relatively weak, and is more sensitive to the environment.

II. Pharmaceutical Areas Suitable for Sustained-Release Capsules
Due to its unique advantages, sustained-release hollow capsules are suitable for the following pharmaceutical areas:
1. Cardiovascular Disease Medications
These include antihypertensive drugs (such as nifedipine sustained-release capsules) and anti-arrhythmic drugs, which require a stable and long-term release to maintain efficacy and prevent fluctuations in blood drug concentration.
2. Analgesic Drugs
For example, morphine sustained-release capsules, suitable for patients with chronic pain, can continuously control pain for 12 hours and reduce the frequency of medication intake.
3. Anti-inflammatory Drugs
Ibuprofen sustained-release capsules are used to relieve mild to moderate pain (such as headache, toothache, joint pain), providing extended pain relief through slow release.
4. Anti-psychotic Drugs
For instance, the antidepressant drug venlafaxine hydrochloride sustained-release capsules, which stabilize blood drug concentration to enhance therapeutic effects while reducing adverse reactions.
5. Lipid-Lowering Drugs
For example, fenofibrate choline sustained-release capsules, used to regulate blood lipids, requiring only one daily dose to improve patient medication convenience.
6. Other Areas Requiring Long-Term Medication
Including anti-ulcer drugs, antipyretic analgesics, etc. These drugs use sustained-release technology to reduce irritation to the gastrointestinal tract and extend the duration of action.

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