Acid-resistant Capsules

Hubei Kornnac Pharmaceutical Co., Ltd. is one of the most reliable manufacturers and suppliers of acid-resistant capsules in China, also supports customized service and OEM service. Welcome to buy bulk high quality acid-resistant capsules at competitive price from our factory. Contact us for samples.

Acid-resistant capsules‌ are designed to withstand gastric acid erosion, allowing medications to pass through the stomach intact without degradation and releasing the drug in the intestines. This formulation aims to protect drug stability in acidic gastric environments or enable targeted drug delivery to specific intestinal regions. For example, certain probiotic capsules use acid-resistant technology to ensure live probiotics survive passage through the stomach, ultimately regulating gut flora in the intestines.

♦Substances for which the effectiveness of their ingredients is reduced by acidity: Lactobacillus and Bifidobacterium species;

♦Substances with a powerful irritant effects on the gastric mucosa: hot peppers (capsaicin), garlic, etc.;

♦Substances that may cause bad breath: garlic, DHA/EPA (fish oils), shark liver oil, etc.

♦Gelatin capsule: After 30 minutes in gastric acid environment, it is almost completely dissolved and has no protective effect on the contents.
♦HPMC capsule: After 120 minutes in gastric acid environment, the dissolution rate reaches 55.8%, and the effective ingredients have been destroyed.
♦Acid-resistant HPMC Capsule: After 120 minutes in gastric acid environment, the dissolution rate is less than 10%, which can withstand the test of gastric acid; the dissolution rate in the intestinal environment for 45 minutes reaches 89.18%, which can fully exert the maximum effect of intestinal absorption.

▶Equipped with PTS Production Lines, with intelligent sol-gel system,automatic viscosity adjustment equipment, Automatic Guided Vehicle System, vacuum pipeline for capsule transmission, with fully-automatic control and operation, core process technology for guarantee, traceable for the procedures, with the higher quality.

 

▶Achieved through fully automated control systems, strict indoor cleaning protocols, comprehensive quality monitoring, and stable temperature and humidity conditions-ensuring a safe, clean, and contamination-free production environment.

 

▶Acid-base sensitive properties protect the active ingredients from being destroyed by gastric acid, and are designed to dissolve quickly in the intestines, making them very suitable for products with probiotics, enzymes, and other formulas.

 

▶Low water content, suitable for hygroscopic powders.

 

▶No allergens, no genetic modification, no preservatives.

 

▶Certified by the International Kosher, Halal, and Vegetarian Association, FDA,ISO9001 and ISO22000.

Our product complies with the standards of the Chinese Pharmacopoeia and has passed international certifications such as HALAL,Kosher,FDA,ISO9001 and ISO22000.

▶Product Services

Kornnaccaps offers formula optimization to meet diverse functional requirements, alongside custom color solutions and versatile printing methods for brand differentiation.

 

▶Transportation Services

Post-inspection, we promptly arrange tailored logistics-specialized trucks, refrigerated transport, air freight, and express services-to fulfill global supply needs efficiently.

 

▶ After-Sales Services
12-Hour Response Policy: Dedicated sales, technical, and after-sales teams address quality inquiries within 12 hours.

Packaging

● PE bag+Aluminum foil bag+Six surface foam board+5 ply corrugated Carton

● Carton size 60x73x40cm,volume 0.18 cubic meters,gross weight is about 15kgs per box

● 20' Refrigerator Container : 140 cartons empty capsules.

● 40' Refrigerator Container: 345 cartons empty capsules.

 

Storage

1.Store capsules in a clean room where the temperature is maintained between 10°C to 25°C and the relative humidity is between 35% to 65%.

2.Capsule cartons should be kept away from walls and elevated from the floor to prevent moisture accumulation.

3.Avoid direct sunlight, and keep capsules away from heat sources and water to maintain product integrity.

 

Available for customization according to the customer's requirements.

Types of HPMC Capsules Based on Release Characteristics
As pharmaceutical and nutraceutical formulations become increasingly sophisticated, HPMC (Hydroxypropyl Methylcellulose) capsules offer versatile drug delivery solutions. Among their advanced types, acid-resistant, enteric, and sustained-release capsules play crucial roles in protecting active ingredients and achieving controlled drug release in specific segments of the gastrointestinal (GI) tract.

Acid-Resistant HPMC Capsules:
In a hydrochloric acid medium with pH 1.2, the capsules do not disintegrate or release contents within 30 minutes.

Application:
Ideal for protecting acid-sensitive ingredients or reducing stomach irritation by postponing release until the upper intestine. Often used for probiotics, enzymes, or herbal actives.

Enteric HPMC Capsules:
In a hydrochloric acid medium with pH 1.2, the capsules remain intact for 2 hours without disintegration. Once transferred to a pH 6.8 phosphate buffer medium, they completely disintegrate within 1 hour.

Application:
Suitable for drugs that are inactivated by stomach acid or irritate the stomach lining. Commonly used for NSAIDs, antibiotics, or certain nutritional supplements.

Sustained-Release Capsules:
Sustained release is a broader concept, encompassing both acid-resistant and enteric capsules. It refers to the gradual release of active ingredients in the body, which can be achieved by using specially designed capsules or applying specific treatments to the powder formulation.

Application:
SR capsules are widely used in chronic conditions requiring consistent blood drug levels, such as hypertension, diabetes, or mental health disorders.

Conclusion
HPMC capsules provide a plant-based, stable, and highly customizable delivery system. By choosing the appropriate type-acid-resistant, enteric, or sustained-release-manufacturers can optimize therapeutic performance, enhance patient compliance, and reduce dosing frequency. Their adaptability to different active substances and formulation needs makes HPMC capsules a preferred choice in modern pharmaceutical development.

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