Size 1 Enteric Coated Capsules

Hubei Kornnac Pharmaceutical Co., Ltd. is one of the most reliable manufacturers and suppliers of size 1 enteric coated capsules in China, also supports customized service and OEM service. Welcome to buy bulk high quality size 1 enteric coated capsules at competitive price from our factory. Contact us for samples.

Enteric Coated Gelatin Capsules can release the drug at the targeted position in the intestnal tract and make the contents begin being absorbed in the upper part of the small intestine, improving the bioavailability of the contents. At the same time, it avoids the strong stimulation of the contents to gastric mucosa. The capsule is featured with the same appearance and good filling property of the empty gelatin capsule and suitable for different types of automatic filling machines.

▶cGMP QUALITY MANAGEMENT STANDARDS

 

Follow cGMP to organize production and quality management, establishing a quality assurance system, and the laboratory will carry out CNAS certification.

 

▶SMART SOL-GEL

 

Fully-automatic operation of sol gel and viscosity, core technology to ensure the quality of gel liquid. Process traceability for more stable quality.

 

▶INFORMATIZATION MANAGEMENT

 

Designed by lBM for the informatization management of the enterprise, including ERP,MES, SCADA, LIMS, WMS and other related systems.

 

▶Strictly MANAGEMENT STANDARDS

 

In enteric coated capsules by our company complies with strictly international pharmaceutical excipients standard management, passed ISO 9001 Quality Management System Certification, we always regard scientific,standardized, high-quality as our responsibility.

• In order to produce high-quality, safe, healthy empty capsules, every step of the production is with strict operation procedures and quality control.

 

• From the choosing of raw material, to the focus on production process and the inspection of the finished capsules, all strictly in accordance with the standards.

Control

1. Raw material

2. Test raw material

3. Melting

4. Capsule production

5. Printing(be requested)

6. Inspection by machine

7. Counting and packing

8. Product inspection in lab

Kornnaccaps products meet Chinese Pharmacopoeia standards and hold international certifications including HALAL, Kosher, FDA, ISO 9001, and ISO 22000-ensuring global market readiness.

1. Excellent lead time with sufficient supply quantity;

 

2. Response time to quality problems: within 12 hours, the sales, technical and after-sales departments will make a joint response;

 

3. Provide customers with free training of filling machine maintenance, operation and capsule inspection knowledge, to better solve customers' actual problems;

 

4. Provide filling machine installation, debugging, repair and maintenance services free of charge, and assist customers in ordering filling machine spare parts;

 

5. Free samples for testing;

 

6. Comprehensive after-sales technical support;

 

7. Customized capsules according to the characteristics of customer powder.

Packing

● PE bag+Aluminum foil bag+Six surface foam board+5 ply corrugated Carton;

● Carton size: 60x73x40cm; volume: 0.18 cubic meters; gross weight is about 15kgs per box.

● 20' Refrigerator Container: 140 cartons empty capsules;

● 40' Refrigerator Container: 345 cartons empty capsules.

 

Shipping

After product inspection, we promptly arrange transportation based on customer requirements - including dedicated trucks, refrigerated vehicles, air freight, and express delivery - to efficiently meet the diverse supply needs of our clients.

 

Available for customization according to the customer's requirements.

Enteric Coated Capsules: Dissolution Mechanism, Applications, and Comparison with Other Capsule Types

Enteric coated capsules are designed to remain intact in the acidic environment of the stomach and dissolve only once they reach the more neutral or alkaline conditions of the small intestine. This property is achieved through a special coating made from pH-sensitive polymers such as hydroxypropyl methylcellulose phthalate (HPMCP), methacrylic acid copolymers, or cellulose acetate phthalate.

Dissolution Mechanism

The enteric coating of these capsules is formulated to resist dissolution at low pH levels (typically around pH 1.2 in the stomach). As the capsule travels through the gastrointestinal tract and reaches the small intestine (usually around pH 5.5 to 7.0), the coating begins to ionize and dissolve. Once dissolved, the capsule releases its contents in the intestinal environment, where many drugs are better absorbed or are less likely to degrade.

This pH-triggered dissolution protects acid-sensitive ingredients from degradation in the stomach and ensures that drugs or supplements are delivered to the site where they are most effective or least irritating.

Applications

Enteric coated capsules are widely used in both pharmaceutical and nutraceutical industries. Common applications include:

Acid-sensitive medications, such as proton pump inhibitors (e.g., omeprazole), which are ineffective if released in the stomach.

Probiotics and digestive enzymes, which may lose potency in acidic environments.

Non-steroidal anti-inflammatory drugs (NSAIDs), which can irritate or damage the gastric lining.

Herbal or bitter-tasting compounds, where delayed release can improve patient compliance.

Comparison with Other Capsules

While enteric coated capsules serve a specific function, they are often confused with other types like acid-resistant capsules and sustained release capsules. Here's how they differ:

In summary, enteric coated capsules offer a targeted delivery system based on pH sensitivity, making them ideal for drugs and supplements that should not be released in the stomach. While acid-resistant and sustained release capsules may share some features, they serve distinct purposes and use different technologies. Understanding these differences is essential for selecting the right capsule for a specific formulation.

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